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VirScan® - Viral PhIP-Seq Antibody Profiling Services

Pan-viral Proteomes in a Single Assay

Most viral proteomes epitope-level autoantibody profiling service via T7 phage display and Phage ImmunoPrecipitation Sequencing (PhIP-Seq).

VIRSCAN PHIP-SEQ
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HuScan® Human Proteome PhIP-Seq

Detects Antibodies Against 48,921 Unique Human Proteins

HuScan PhIP-Seq is composed of an entire normal human proteome as defined by the NCBI RefSeq database.

HUSCAN PHIP-SEQ
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MouseScan® Murine Proteome PhIP-Seq

Detects Antibodies Against 50,135 Unique Murine Proteins

Murine proteome epitope-level autoantibody profiling services via T7 phage display and Phage ImmunoPrecipitation Sequencing (PhIP Seq).

MOUSESCAN PHIP-SEQ
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CDI Labs Autoantibody Profiling Services

High-throughput Autoantibody Signature Validation

CDI Labs offers high-throughput focused array services to validate autoantibody signatures discovered with the HuProt Microarray.

HUPROT SERVICES

The World's Most Comprehensive Portfolio for Autoantibody Detection and Target ID

Transformational products and services for proteome-wide autoantibody profiling, biomarker discovery, cross-reactivity screening, and other whole-proteome target identification and interaction assays

PhIP-Seq Combines DNA High-throughput Sequencing with Next-Gen Proteomics

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Pan-viral Proteomes

Detects antibodies against 68,000+ vertebrate viral protein sequences

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All Human Proteome

Detects antibodies against 48,921 unique human proteins and protein isoforms

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All Murine Proteome

Detects antibodies against 50,135 unique murine proteins and protein isoforms

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21,000+ Full-length Proteins

GST-purified and validated recombinant proteins and isoform variants

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Cell Membrane-embedded

Purified virion display correctly-folded membrane-embedded GPCRs

HuProt™ and VirD™ are provided by CDI Labs.

CDI Labs Autoantibody Seromics

The serome is the total secreted antibody repertoire of a single individual; each serome is unique and created by a person's lifetime of adaptive immune experiences. The goal of the emerging scientific field of autoantibody seromics is to understand the largest impacts of the serome on human health, disease, and clinical outcomes.

PUBLICATION HIGHLIGHT

Human virome profiling identified CMV as the major viral driver of a high accumulation of senescent CD8+ T cells in patients with advanced NSCLC

AUTHORS

Marie Naigeon, François-xavier Danlos, Lisa Boselli, Jean-mehdi Jouniaux, Caroline De Oliveira, Roberto Ferrara, Boris Duchemann, Caroline Berthot, Lou Girard, Ronan Flippot, Laurence Albiges, Siham Farhane, Patrick Saulnier, Ludovic Lacroix, Frank Griscelli, Gabriel Roman, Tyler Hulett, Aurélien Marabelle, Lydie Cassard, Benjamin Besse, and Nathalie Chaput

ABSTRACT

Circulating senescent CD8+ T (T8sen) cells are characterized by a lack of proliferative capacities but retain cytotoxic activity and have been associated to resistance to immunotherapy in patients with advanced non–small cell lung cancer (aNSCLC). We aimed to better characterize T8sen and to determine which factors were associated with their accumulation in patients with aNSCLC. Circulating T8sen cells were characterized by a higher expression of SA-βgal and the transcription factor T-bet, confirming their senescent status. Using whole virome profiling, cytomegalovirus (CMV) was the only virus associated with T8sen. CMV was necessary but not sufficient to explain high accumulation of T8sen (T8senhigh status). In CMV+ patients, the proportion of T8sen cells increased with cancer progression. Last, CMV-induced T8senhigh phenotype but not CMV seropositivity itself was associated with worse progression-free and overall survival in patients treated with anti–PD-(L)1 therapy but not with chemotherapy. Overall, CMV is the unique viral driver of T8sen-driven resistance to anti–PD-(L)1 antibodies in patients with advanced NSCLC.

More Content and Better Data

We start with sequence-confirmed plasmids, then individually express and GST-purify proteins from S. cerevisiae. Piezolelectric printing is used to spot these in duplicate alongside controls. Quality is confirmed with anti-GST QA/QC. Successful folding demonstrated by kinase autophosphorylation assay.

PUBLICATIONS

260+peer-reviewed publications

With over 260 publications (and growing), our antibody seromics solutions and HuProt array continue to play a key role in life sciences by contributing to critical studies that help accelerate research, advance discoveries, and translate discoveries to novel products that improve human health.

CUSTOMER-BASE

190+customer base

Our customer base continues to expand throughout North America, Europe, and Asia Pacific, and is a testament to the quality and consistency of our products and services.

FOUNDERS

Boeke, Zhu & Blackshawat Johns Hopkins University

Funded by NIH Common Fund Support for the Development of Protein Capture Reagents and Technologies, the HuProt Protein Microarray was created by CDI Labs co-founders Jef Boeke, Heng Zhu, Dan Eichinger, and Seth Blackshaw, faculty members at the High Throughput Biology (HIT) Center at the Johns Hopkins University School of Medicine.

Data and technology validated by scientists

"This (VirScan) assay, which uses phage display immunoprecipitation and sequencing, is a sensitive and focused high-comprehensive approach that enables thorough serological profiling of antiviral antibodies in humans and, consequently, the identification of viral exposure throughout the human virome."

Faculty of MedicineResearch Institution (as mentioned in "Human virome profiling identified CMV as the major viral driver of a high accumulation of senescent CD8+ T cells in patients with advanced NSCLC" - Science Advances - November 2023)

Data and technology validated by scientists

"We elected to use the HuProt Microarray because it is an extensive platform that contains over 21,000 unique, individually purified full-length human proteins and protein isoforms in duplicate, covering more than 81% of the proteome."

OncologistSchool of Medicine Research (as mentioned in "Baseline Serum Autoantibody Signatures Predict Recurrence and Toxicity in Melanoma Patients Receiving Adjuvant Immune Checkpoint Blockade" - AACR Clinical Caner Research - September 2022)

Data and technology validated by scientists

"By using (HuProt) protein arrays, we were able to evaluate a broader range of antigens compared to previous investigations."

Senior ScientistBiotech Research (poster presentation at the San Antonio Breast Cancer Symposium 2023)

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  • Jul 9
  • |
  • 2024
CDI Labs Launches New VirScan, HuScan, and MouseScan Services for Massively Multiplexed Analysis of Serum Antibodies

Press Release

CDI Labs Launches New VirScan, HuScan, and MouseScan Services for Massively Multiplexed Analysis of Serum Antibodies

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  • Aug 2
  • |
  • 2023
Barney E. Saunders Ph.D. has been appointed Chief Executive Officer of CDI Laboratories

Press Release

Barney E. Saunders Ph.D. has been appointed Chief Executive Officer of CDI Laboratories

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  • Jan 9
  • |
  • 2023
BroadOak Capital Partners Invests in CDI Laboratories to Expand and Scale Antibody Biomarker Discovery Platforms

Press Release

BroadOak Capital Partners Invests in CDI Laboratories to Expand and Scale Antibody Biomarker Discovery Platforms

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  • Sep 23
  • |
  • 2020
CDI Labs HuProt™ Protein Arrays Instrumental in Recent Study of Multisystem Inflammatory Syndrome in Children (MIS-C)

Press Release

CDI Labs HuProt™ Protein Arrays Instrumental in Recent Study of Multisystem Inflammatory Syndrome in Children (MIS-C)

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